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Washington University in St. Louis News & Information > Faculty Experts at Washington University in St. Louis >

Alan R. Templeton

Professor of Biology in Arts & Sciences

Expertise: evolution of HIV, evolutionary and conservation biology, genetic variability, lipid metabolic genes, molecular genetics, natural selection

Bio:
Alan Templeton
Alan Templeton
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Templeton applies molecular genetic techniques and statistical population genetics to a variety of problems in evolutionary and conservation biology. He explores natural selection in various species, genetic variability, the role of lipid metabolic genes in coronary artery disease in humans, and the evolution of HIV within infected patients. Templeton is known for his examination of the "Eve" controversy and for debunking the "Out of Africa Displacement Theory."

WUSTL Contact Information:
Work:(314) 935-6868
Fax:(314) 935-4432
Alt:(314) 935-6867
E-mail:temple_a@biology.wustl.edu
Address:Campus Box 1137
One Brookings Dr.
St. Louis, MO 63130

Education:
  • Ph.D. in Human Genetics at University of Michigan
  • M.A. in Statistics at University of Michigan
  • A.B. in Zoology at Washington University


News Stories & Tip Sheets:

Showing Stories 1 through 8 of 8.  - Show Home
Tracing origins

Technique traces origins of disease genes in mixed races

April 8, 2008 -- A team of researchers from Washington University in St. Louis that includes Alan R. Templeton and the Israeli Institute of Technology (Technion) in Haifa has developed a technique to detect the ancestry of disease genes in hybrid, or mixed, human populations. The technique, called expected mutual information (EMI), determines how a set of DNA markers is likely to show the ancestral origin of locations on each chromosome.


Those wild ancestors

Schaal and collaborators locate rice domestication using DNA

Sept. 7, 2006 --
Schaal rice one.
Photo courtesy USDA
Schaal rice one.
Biologists from Washington University in St. Louis and their collaborators from Taiwan have examined the DNA sequence family tree of rice varieties and have determined that the crop was domesticated independently at least twice in various Asian locales. Jason Londo, Washington University in Arts & Sciences biology doctoral candidate, and his adviser, Barbara A. Schaal, Ph.D., Washington University Spencer T. Olin Professor of Biology in Arts & Sciences, ran genetic tests of more than 300 types of rice, including both wild and domesticated, and found genetic markers that reveal the two major rice types grown today were first grown by humans in India and Myanmar and Thailand (Oryza sativa indica) and in areas in southern China (Oryza sativa japonica). More...


'It's a jungle out there'

Competition for sex is brutal in biodiversity hotspots

Feb. 2, 2006 --
Good pollinators wanted
Good pollinators wanted
Mother Nature could use a few more good pollinators, especially in species-rich biodiversity hotspots, according to a new study in the Proceedings of the National Academy of Science (PNAS online, Jan. 16, 2006). Jana Vamosi, Ph.D, postdoctoral associate at the University of Calgary and Tiffany Knight, Ph.D., assistant professor of biology in Arts & Sciences at Washington University in St. Louis, and their collaborators have performed an exhaustive global analysis of more than 1,000 pollination studies which included 166 different plant species and found that, in areas where there is a great deal of plant diversity, plants suffer lower pollination and reproductive success. For some plant species, this reduction in fruit and seed production could push them towards extinction.


Make love, not war

African populations interbred with Eurasians and stayed a while

Feb. 2, 2006 --
A new, more robust analysis of recently derived human gene trees by Alan R. Templeton, Ph.D, of Washington University in St Louis, shows three distinct major waves of human migration out of Africa instead of just two, and statistically refutes — strongly — the 'Out of Africa' replacement theory. That theory holds that populations of Homo sapiens left Africa 100,000 years ago and wiped out existing populations of humans. Templeton has shown that the African populations interbred with the Eurasian populations — thus making love, not war.


Can't we just all get along?

Early man cooperative, wary, wise, not a warrior

July 7, 2005 --
Some species still prey on humans to this day.
Some species still prey on humans to this day.
Early man was more wary than war-like, more intelligent, agile, and cooperative than aggressive, predator or killer, and he co-evolved as the prey of many species. Moreover, in the old days, woman wore the pants in the family and men were basically expendable, not the brightest bulbs on the tree when it came to tools, and functioning best as sentinels wary of predators in edge environments between the forest and savannah. Those are the primary themes of a new book, "Man the Hunted: Primates, Predators and Human Evolution", co-authored by Robert W. Sussman, Ph.D., professor of anthropology in Arts & Sciences.


Lizards: A Florida export

Researchers show migrations stem from Florida

Sept. 15, 2004 --
Photo courtesy U.S. Geological Survey/SOFIA
Genetic studies performed by Washington University biologists shows that the sunshine State is the exporter of brown lizards to other countries.
A new study headed by biologists at Washington University in St. Louis shows that Florida is an exporter of more than just fruit and star athletes. Studying genetic variation in the common brown lizard, Anolis sagrei, the researchers found that introduced populations of the lizard in five different countries can be traced back to the Sunshine State as their site of export.


'The meaning of being human'

World's top scholars on modern human origins to gather at Washington University

March 18, 2004 -- Some of the world's top scholars on modern human origins will gather March 26 at Washington University in St. Louis for the last of a four-part series of "Conversations" on key issues that will affect the future of the university, the community and the world. Arts & Sciences is sponsoring the "Conversations," which are free and open to the public, as part of the university's 150th anniversary celebration. The "Modern Human Origins" Conversation will be held from 10 to 11:30 a.m. in Graham Chapel.


'Genetic interconnections all over the globe'

Evolutionary biologist: race in humans a social, not biological, concept

May 20, 2003 --
Alan Templeton
Templeton
The notion of race in humans is completely a social concept without any biological basis, according to a biologist at Washington University in St. Louis. There are not enough genetic differences between groups of people to say that there are sub-lineages (races) of humans, said Alan R. Templeton, Ph.D., professor of biology in Arts & Sciences at Washington University in St. Louis. On the other hand, there are different races in many other species, including chimpanzees, our closest evolutionary relatives. Templeton was part of a recent St. Louis panel discussion that previewed the first episode of the National Public Television's "Race: The Power of an Allusion" series running nationally on May 4, 11, and 18 (check local stations for times).



Showing Stories 1 through 8 of 8.  - Show Home

Additional Background: Templeton applies molecular genetic techniques and statistical population genetics to a variety of problems in evolutionary and conservation biology. Because many genes have a known function, it is often possible to identify loci that may directly influence some phenotype of interest. Genetic variability at these loci is surveyed molecularly and tested for phenotypic associations. He is using this approach to study natural selection in various species, to examine the role of lipid metabolic genes in coronary artery disease in humans, and to investigate the evolution of HIV within infected patients. So much variation is detected at candidate loci at the molecular level that it is often difficult to identify the handful of mutations that are associated with significant phenotypic effects. To solve this problem, he constructs an evolutionary tree of the genetic variation detected at a locus and use this tree to define a nested statistical analysis. The idea is that any phenotypically important mutation is imbedded in the evolutionary history of the genetic variation at the locus, and therefore phenotypic effects should be non-randomly distributed over the tree. He has shown that this cladistic approach is more powerful than approaches that ignore evolutionary history.

Templeton has extended this cladistic approach to separate the effects of current population structure from past events that occurred in the history of the species, such as fragmentation events and geographical range changes. Such analyses have provided much insight into recent human evolution and also provide a rigorous manner to identify species.


Related Information
Media Assistance:

Diana Lutz
Senior Science Editor
dlutz@wustl.edu

(314) 935-5272
Related Links:
Templeton's Web site
Race in humans a social, not biological, concept

Related Groups:

Departments:
Biology
Genetics

- View All Groups

Related Topics:
Evolution
Genetics
Life Sciences

- View All Topics

Revised:

Friday, Oct. 13, 2006


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